Protective effect of JBP485 on concanavalin A-induced liver injury in mice

200937 citationsJournal Article

Authors

Tao Yang · Dalian Medical University

Jingjing Wu · Dalian Medical University

Changyuan Wang · Dalian Medical University

Qi Liu · Dalian Medical University

Xiaochi Ma · Dalian Medical University

Jinyong Peng · Dalian Medical University

Taiichi Kaku ·

Abstract

These results indicated that immune-mediated liver damage can be prevented by JBP485, and that this is mainly associated with immunomodulatory effects on T cells and adhesion molecules, antioxidation, and inhibition of apoptosis.

Topics & Keywords

Drug-Induced Hepatotoxicity and Protection Liver physiology and pathology Cell death mechanisms and regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Pharmacy and Pharmacology

Volume 61, Issue 6, pp. 767-774

DOI: 10.1211/jpp.61.06.0009

Field-Weighted Citation Impact: 5.51