The Role of Nuclear β-Catenin Accumulation in the Twist2-Induced Ovarian Cancer EMT

201365 citationsJournal Articlegold Open Access

Authors

Yubin Mao · Xiamen University

Jinfei Xu · Xiamen University

Zhihan Li · Xiamen University

Nini Zhang · Xiamen University

Hao Yin · Xiamen University

Zuguo Liu · Xiamen University

Abstract

Our data indicates that upregulation of Twist2 is correlated with the FIGO stage in human ovarian cancers. In this report, we demonstrated that nuclear β-catenin is accumulated in Twist2-induced EMT cells to facilitates ovarian cancer invasion and metastasis.

Topics & Keywords

Wnt/β-catenin signaling in development and cancer RNA Research and Splicing Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 11, pp. e78200-e78200

DOI: 10.1371/journal.pone.0078200

Field-Weighted Citation Impact: 3.29