Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

2012110 citationsJournal Articlebronze Open Access

Authors

Ronnatrai Rueangweerayut · Maesot General Hospital

Aung Pyae Phyo · Shoklo Malaria Research Unit

Chirapong Uthaisin

Poravuth Yi · Cambodia National Malaria Center

Trần Quang Bình · Cho Ray Hospital

Halidou Tinto · Centre Muraz

Louis K. Pénali · Institut Pasteur de Côte d'Ivoire

Abstract

Fixed-dose pyronaridine-artesunate was efficacious in the treatment of uncomplicated P. falciparum malaria. In Cambodia, extended parasite clearance times were suggestive of in vivo resistance to artemisinin. (Funded by Shin Poong Pharmaceutical Company and the Medicines for Malaria Venture; ClinicalTrials.gov number, NCT00403260.).

Topics & Keywords

Malaria Research and Control Computational Drug Discovery Methods Mosquito-borne diseases and control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 366, Issue 14, pp. 1298-1309

DOI: 10.1056/nejmoa1007125

Field-Weighted Citation Impact: 10.65