<i>Global status report on road safety</i>

<h3>Objective.</h3> To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. <h3>Methods.</h3> Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid &gt; 7 mg/dl). <h3>Results.</h3> Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p &lt; 0.01) and serum creatinine by 0.17 mg/dl (p &lt; 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. <h3>Conclusion.</h3> Prednisone can be used safely in symptomatic HF patients with hyperuricemia.