Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.

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Authors

K Shimotohno · National Institute of Genetics

Yoshiko Takahashi · National Institute of Genetics

N. Shimizu · National Institute of Genetics

Takashi Gojobori · University of California, Los Angeles

David W. Golde · University of California, Los Angeles

I S Chen · University of California, Los Angeles

Masanao Miwa

Abstract

The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.

Topics & Keywords

T-cell and Retrovirus Studies Animal Disease Management and Epidemiology Vector-Borne Animal Diseases

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Proceedings of the National Academy of Sciences

Volume 82, Issue 10, pp. 3101-3105

DOI: 10.1073/pnas.82.10.3101

Field-Weighted Citation Impact: 9.54