Galectin-9 Inhibits CD44–Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma

2007159 citationsJournal Article

Authors

Shigeki Katoh · Kagawa University

Naoki Ishii · Galena Biopharma (United States)

Atsuya Nobumoto · Bipar

Keisuke Takeshita · Galena Biopharma (United States)

Shuyan Dai · Bipar

Rika Shinonaga · Galena Biopharma (United States)

Toshiro Niki ·

Abstract

We conclude that Gal-9 inhibits allergic inflammation of the airway and AHR by modulating CD44-dependent leukocyte recognition of the extracellular matrix.

Topics & Keywords

Galectins and Cancer Biology Glycosylation and Glycoproteins Research Invertebrate Immune Response Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 176, Issue 1, pp. 27-35

DOI: 10.1164/rccm.200608-1243oc

Field-Weighted Citation Impact: 3.44