Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2001679 citationsJournal Articlebronze Open Access

Authors

Saul N. Faust · St Mary's Hospital

Michael Levin · St Mary's Hospital

Odile B. Harrison · St Mary's Hospital

Robert Goldin · St. Mary’s Hospital

Marion S. Lockhart · Oklahoma City University

Sheila Kondaveeti · St Mary's Hospital

Zoltán Lászik · University of Oklahoma Health Sciences Center

Abstract

In severe meningococcal sepsis, protein C activation is impaired, a finding consistent with down-regulation of the endothelial thrombomodulin-endothelial protein C receptor pathway.

Topics & Keywords

Blood Coagulation and Thrombosis Mechanisms Sepsis Diagnosis and Treatment Venous Thromboembolism Diagnosis and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 345, Issue 6, pp. 408-416

DOI: 10.1056/nejm200108093450603

Field-Weighted Citation Impact: 22.89