Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention

20023,074 citationsJournal Article

Authors

Steven R. Steinhubl · University of North Carolina at Chapel Hill

Peter B. Berger · American Medical Association

J. Tift Mann · University of North Carolina at Chapel Hill

Edward T.A. Fry · University of North Carolina at Chapel Hill

Augustin DeLago · University of North Carolina at Chapel Hill

Charles Wilmer · University of North Carolina at Chapel Hill

Eric J. Topol

Abstract

Following PCI, long-term (1-year) clopidogrel therapy significantly reduced the risk of adverse ischemic events. A loading dose of clopidogrel given at least 3 hours before the procedure did not reduce events at 28 days, but subgroup analyses suggest that longer intervals between the loading dose and PCI may reduce events.

Topics & Keywords

Antiplatelet Therapy and Cardiovascular Diseases Coronary Interventions and Diagnostics Atrial Fibrillation Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 288, Issue 19, pp. 2411-2411

DOI: 10.1001/jama.288.19.2411

Field-Weighted Citation Impact: 88.39