Preparation of Biocompatible Magnetite Nanocrystals for In Vivo Magnetic Resonance Detection of Cancer

Biocompatible Fe3O4 magnetic nanocrystals with reactive moieties on the surface can be prepared via a “one-pot” reaction and used straightforwardly in cancer detection by being coupled with a specific cancer-targeting antibody. It is demonstrated that the as-prepared Fe3O4 nanocrystals can potentially be used as effective magnetic resonance imaging (MRI) contrast agents for cancer diagnosis (see figure). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c0385_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.