Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

2011219 citationsJournal Articlegold Open Access

Authors

Pin-Shern Chen · Chia Nan University of Pharmacy and Science

Yuan‐Wei Shih · Chung Hwa University of Medical Technology

Hsiang-Ching Huang · Chia Nan University of Pharmacy and Science

Hsing-Wen Cheng · Chia Nan University of Pharmacy and Science

Abstract

The results suggested that diosgenin inhibited migration and invasion of PC-3 cells by reducing MMPs expression. It also inhibited ERK, JNK and PI3K/Akt signaling pathways as well as NF-κB activity. These findings reveal new therapeutic potential for diosgenin in anti-metastatic therapy.

Topics & Keywords

Phytochemical Studies and Bioactivities Marine Sponges and Natural Products Phytochemistry and Bioactive Compounds

Publication Details

Published in: PLoS ONE

Volume 6, Issue 5, pp. e20164-e20164

DOI: 10.1371/journal.pone.0020164

Field-Weighted Citation Impact: 6.11

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Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Authors

Abstract

Topics & Keywords

Publication Details