Disrupted Topological Organization in White Matter Structural Networks in Amnestic Mild Cognitive Impairment: Relationship to Subtype

The present study suggests early onset disruption of whole-brain white matter connectivity in patients with aMCI, especially in those with the MD subtype, supporting the view that MD aMCI is a more advanced form of disease than is SD aMCI. Moreover, cognitive correlations with topological network properties suggest their potential use as markers to assess the risk of Alzheimer disease.