GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

2010173 citationsJournal Articlebronze Open Access

Authors

Patrick Roth · Heidelberg University

Markus Junker · University Hospital Heidelberg

Isabel Tritschler · University Hospital Heidelberg

Michel Mittelbronn · St Vincent's Hospital

Yvonne Dombrowski · Goethe University Frankfurt

Samuel N. Breit · Heidelberg University

Ghazaleh Tabatabai

Abstract

Although previous studies focusing on ectopic overexpression of GDF-15 have proposed unclear or antitumorigenic effects of GDF-15 in glioma cells, we here show that GDF-15 at endogenous levels contributes to proliferation and immune escape of malignant gliomas in an immunocompetent host.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 16, Issue 15, pp. 3851-3859

DOI: 10.1158/1078-0432.ccr-10-0705

Field-Weighted Citation Impact: 3.98