Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y <i>PCSK9</i> Under Physiological Genetic Control

201077 citationsJournal Article

Authors

Bronwen Herbert · MRC London Institute of Medical Sciences

Dilipkumar Patel · MRC London Institute of Medical Sciences

Simon N. Waddington · MRC London Institute of Medical Sciences

Emily R. Eden · MRC London Institute of Medical Sciences

Alexandra McAleenan · MRC London Institute of Medical Sciences

Xi‐Ming Sun · MRC London Institute of Medical Sciences

Anne K. Soutar

Abstract

The expression of human D374Y PCSK9 at physiological levels produced a phenotype that closely matched that found in heterozygous D374Y patients and suggested that reduced low-density lipoprotein receptor activity is not the sole cause of their hypercholesterolemia.

Topics & Keywords

Lipoproteins and Cardiovascular Health Nuclear Receptors and Signaling

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 30, Issue 7, pp. 1333-1339

DOI: 10.1161/atvbaha.110.204040

Field-Weighted Citation Impact: 7.70

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Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y <i>PCSK9</i> Under Physiological Genetic Control

Authors

Abstract

Topics & Keywords

Publication Details