Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal Cord Injury: Correlation of Engraftment with Recovery

2009108 citationsJournal Articlegold Open Access

Authors

Mitra J. Hooshmand · University of California, Irvine

Christopher J. Sontag · University of California, Irvine

Nobuko Uchida · StemCells (United States)

Stan Tamaki · StemCells (United States)

Aileen J. Anderson · University of California, Irvine

B. Cummings · University of California, Irvine

Abstract

Altogether, the data suggest that the locomotor improvements associated with hCNS-SCns transplantation were not due to modifications within the host microenvironment, supporting the hypothesis that human cell integration within the host circuitry mediates functional recovery following a 9 day delayed transplant.

Topics & Keywords

Spinal Cord Injury Research Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms

Publication Details

Published in: PLoS ONE

Volume 4, Issue 6, pp. e5871-e5871

DOI: 10.1371/journal.pone.0005871

Field-Weighted Citation Impact: 5.90

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Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal Cord Injury: Correlation of Engraftment with Recovery

Authors

Abstract

Topics & Keywords

Publication Details