Transforming growth factor-/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity

200839 citationsJournal Articlegreen Open Access

Authors

Minna Anthoni · Immunotope (United States)

Nanna Fyhrquist · Immunotope (United States)

Henrik Wolff · Kymenlaakson keskussairaala

Harri Alenius · Immunotope (United States)

Antti Lauerma · Finnish Institute of Occupational Health

Abstract

The lack of intact TGF-beta signalling via Smad3 results in an increased proinflammatory, Th2 and Th17 type response in the skin, as well as increased expression of regulatory elements such as TGF-beta and Foxp3. Understanding the role of Smad3 in the CHS response may offer treatment and prevention strategies in this often disabling disease.

Topics & Keywords

Asthma and respiratory diseases Immune Response and Inflammation NF-κB Signaling Pathways

Publication Details

Published in: British Journal of Dermatology

Volume 159, Issue 3, pp. ???-???

DOI: 10.1111/j.1365-2133.2008.08696.x

Field-Weighted Citation Impact: 2.77

Command Palette

Transforming growth factor-/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity

Authors

Abstract

Topics & Keywords

Publication Details