Three DNA Methylation Epigenotypes in Human Colorectal Cancer

2009222 citationsJournal Articlebronze Open Access

Authors

Koichi Yagi · The University of Tokyo

Kiwamu Akagi · The University of Tokyo

Hiroshi Hayashi · The University of Tokyo

Genta Nagae · Saitama Cancer Center

Shingo Tsuji · The University of Tokyo

Takayuki Isagawa · The University of Tokyo

Yutaka Midorikawa ·

Abstract

Three methylation epigenotypes exist in colorectal cancer, and suitable classification markers have been developed. Intermediate-methylation epigenotype with KRAS-mutation(+) correlated with worse prognosis.

Topics & Keywords

Epigenetics and DNA Methylation Genetic factors in colorectal cancer Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 16, Issue 1, pp. 21-33

DOI: 10.1158/1078-0432.ccr-09-2006

Field-Weighted Citation Impact: 8.01