Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

2015284 citationsJournal Articlegold Open Access

Authors

Ji‐chun Zhang · Peking University

Jin Wu · Peking University

Yūkō Fujita · Center for Forensic Mental Health, Chiba University

Wei Yao · Peking University

Qian Ren · Peking University

Chun Yang · Center for Forensic Mental Health, Chiba University

Su‐Xia Li ·

Abstract

The results suggest that LPS-induced inflammation may cause depression-like behavior by altering BDNF and spine density in the CA3, DG, PFC, and NAc, which may be involved in the antidepressant effects of 7,8-DHF and ANA-12, respectively.

Topics & Keywords

Tryptophan and brain disorders Stress Responses and Cortisol Treatment of Major Depression

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The International Journal of Neuropsychopharmacology

Volume 18, Issue 4

DOI: 10.1093/ijnp/pyu077

Field-Weighted Citation Impact: 10.52