Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway

201468 citationsJournal Articlegold Open Access

Authors

Luiza F Andrade · Centro de Excelência em Bioinformática

Marina de Moraes Mourão · Fundação Oswaldo Cruz

Juliana Assis Geraldo · Fundação Oswaldo Cruz

Fernanda Sales Coelho · Centro de Excelência em Bioinformática

Larissa Lopes Silva · Centro de Excelência em Bioinformática

Renata Heisler Neves · Universidade do Estado do Rio de Janeiro

Ângela C. Volpini

Abstract

We conclude that MAPKs proteins play important roles in the parasite in vivo survival, being essential for normal development and successful survival and reproduction of the schistosome parasite. Moreover SmERK and SmJNK are potential targets for drug development.

Topics & Keywords

Parasites and Host Interactions Trace Elements in Health Parasite Biology and Host Interactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS neglected tropical diseases

Volume 8, Issue 6, pp. e2949-e2949

DOI: 10.1371/journal.pntd.0002949

Field-Weighted Citation Impact: 6.39