Association of a Low-Frequency Variant in<i>HNF1A</i>With Type 2 Diabetes in a Latino Population

Using whole-exome sequencing, we identified a single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function. This finding may have implications for screening and therapeutic modification in this population, but additional studies are required.