Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

2012107 citationsReviewhybrid Open Access

Authors

Piotr Wojciechowski · CRE Consulting (Poland)

Anna M. Lipowska · Emory University

P Rys · CRE Consulting (Poland)

Kathryn G. Ewens · University of Pennsylvania

Stephen Franks · Hammersmith Hospital

Susanne Tan · University of Duisburg-Essen

Elisabeth Lerchbaum ·

Abstract

The effect of FTO SNPs on obesity-related traits in PCOS seems to be more than two times greater than the effect found in large population-based studies. This suggests an interaction between FTO and the metabolic context or polygenic background of PCOS.

Topics & Keywords

Ovarian function and disorders Genetic Associations and Epidemiology Ovarian cancer diagnosis and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetologia

Volume 55, Issue 10, pp. 2636-2645

DOI: 10.1007/s00125-012-2638-6

Field-Weighted Citation Impact: 12.69