Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages

Tobacco smoke exposure of human monocytes/macrophages induces cell surface TF display, apoptosis, and ERK- and caspase 3-dependent generation of biologically active procoagulant MVs. These processes may be novel contributors to the pathological hypercoagulability of active and secondhand smokers.