Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

2015564 citationsJournal Articlebronze Open Access

Authors

Nasim Mavaddat · University of Cambridge

Paul D.P. Pharoah · University of Cambridge

Kyriaki Michailidou · University of Cambridge

Jonathan P. Tyrer · University of Cambridge

Mark N. Brook · Institute of Cancer Research

Manjeet K. Bolla · University of Cambridge

Qin Wang ·

Abstract

The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report.

Topics & Keywords

BRCA gene mutations in cancer AI in cancer detection Genetic Associations and Epidemiology

UN Sustainable Development Goals

Gender equality

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 107, Issue 5

DOI: 10.1093/jnci/djv036

Field-Weighted Citation Impact: 49.22