Data management in Thrombin Generation

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Abstract

To obtain a thrombin generation (TG) curve from the conversion of added fluorogenic substrate, thrombin concentrations are to be derived from the observed velocity of increase of fluorescence (dF/dt). The relation between velocity and thrombin concentration varies during the experiment because substrate is consumed and because fluorescence is not linear with the concentration of product. Here we review the techniques that we developed to:

Topics & Keywords

Blood Coagulation and Thrombosis Mechanisms Protease and Inhibitor Mechanisms Venous Thromboembolism Diagnosis and Management

Publication Details

Published in: Thrombosis Research

Volume 131, Issue 1, pp. 3-11

DOI: 10.1016/j.thromres.2012.10.011

Field-Weighted Citation Impact: 2.05

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Data management in Thrombin Generation

Authors

Abstract

Topics & Keywords

Publication Details