Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989423 citationsJournal Article

Authors

Leu‐Fen H. Lin · Synergetics (Belgium)

Drzislav Mismer · Synergetics (Belgium)

Jack D. Lile · Synergetics (Belgium)

Lyman G. Armes · Synergetics (Belgium)

Eugene T. Butler · Synergetics (Belgium)

J L Vannice · Synergetics (Belgium)

Frank M. Collins ·

Abstract

Ciliary neurotrophic factor (CNTF) is one of a small number of proteins with neurotrophic activities distinct from nerve growth factor (NGF). CNTF has now been purified and cloned and the primary structure of CNTF from rabbit sciatic nerve has been determined. Biologically active CNTF has been transiently expressed from a rabbit complementary DNA clone. CNTF is a neural effector without significant sequence homologies to any previously reported protein.

Topics & Keywords

Nerve injury and regeneration Pluripotent Stem Cells Research Pancreatic function and diabetes

Publication Details

Published in: Science

Volume 246, Issue 4933, pp. 1023-1025

DOI: 10.1126/science.2587985

Field-Weighted Citation Impact: 13.81

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Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

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Abstract

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Publication Details