Tolerance Induction in HLA Disparate Living Donor Kidney Transplantation by Donor Stem Cell Infusion

2012152 citationsJournal Article

Authors

Joseph R. Leventhal · Northwestern Memorial Hospital

Michaël Abécassis

Joshua Miller

Lorenzo Gallon

David J. Tollerud · Talaris Therapeutics (United States)

Mary Jane Elliott · University of Louisville

Larry D. Bozulic · Talaris Therapeutics (United States)

Christopher Houston · University of Louisville

Abstract

Low-intensity conditioning plus FCRx safely achieved durable chimerism in mismatched allograft recipients. Sensitization represents an obstacle to successful induction of chimerism. Sustained T-cell chimerism is a more robust biomarker of tolerance than donor-specific hyporeactivity.

Topics & Keywords

Renal Transplantation Outcomes and Treatments Hematopoietic Stem Cell Transplantation T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Transplantation

Volume 95, Issue 1, pp. 169-176

DOI: 10.1097/tp.0b013e3182782fc1

Field-Weighted Citation Impact: 13.31