Constitutive activation of nuclear factor ?B in hepatocellular carcinoma

2000199 citationsJournal Articlebronze Open Access

Authors

Dar‐In Tai · Chang Gung Memorial Hospital

Sun‐Lung Tsai · Chang Gung University

Ya‐Hui Chang · Chang Gung University

Shao-Nan Huang · Chang Gung Memorial Hospital

Tse-Ching Chen · Chang Gung Memorial Hospital

Kenneth S. S. Chang · Chang Gung University

Yun-Fan Liaw ·

Abstract

Constitutive activation of NF-kappaB was found more frequently in tumor tissue compared with nontumor tissue. It is possible that NF-kappaB overexpression accompanied by dysregulation of IkappaBalpha may play a role in the hepatocarcinogenesis of HBV or HCV infection.

Topics & Keywords

NF-κB Signaling Pathways Immune Response and Inflammation Genomics, phytochemicals, and oxidative stress

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 89, Issue 11, pp. 2274-2281

DOI: 10.1002/1097-0142(20001201)89:11<2274::aid-cncr16>3.0.co;2-2

Field-Weighted Citation Impact: 3.11