Bmi1 Enhances Tumorigenicity and Cancer Stem Cell Function in Pancreatic Adenocarcinoma

2013106 citationsJournal Articlegold Open Access

Authors

Erica Proctor · University of Michigan–Ann Arbor

Meghna Waghray · Michigan United

Cheong Lee · University of Michigan–Ann Arbor

David G. Heidt · University of Michigan–Ann Arbor

Malica Yalamanchili · University of Michigan–Ann Arbor

Chenwei Li · University of Michigan–Ann Arbor

Filip Bednar

Abstract

Our results implicate Bmi1 in the invasiveness and growth of pancreatic cancer and demonstrate its key role in the regulation of pancreatic cancer stem cells.

Topics & Keywords

Epigenetics and DNA Methylation Pancreatic function and diabetes Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 2, pp. e55820-e55820

DOI: 10.1371/journal.pone.0055820

Field-Weighted Citation Impact: 6.29