Activation of Cardiac Aldosterone Production in Rat Myocardial Infarction

1999374 citationsJournal Articlebronze Open Access

Authors

Jean‐Sébastien Silvestre · Inserm

Christophe Heymes · Inserm

Abdeslam Oubénaı̈ssa · Inserm

Valérie Robert · Inserm

B. Aupetit-Faisant · Inserm

A. Carayon · Inserm

Bernard Swynghedauw · Inserm

Abstract

MI is associated with tissue-specific activation of myocardial aldosterone synthesis. This increase is mediated primarily by cardiac angiotensin II via AT1-subtype receptor and may be involved in post-MI ventricular fibrosis and in control of tissue norepinephrine concentration.

Topics & Keywords

Hormonal Regulation and Hypertension Apelin-related biomedical research Cardiovascular, Neuropeptides, and Oxidative Stress Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 99, Issue 20, pp. 2694-2701

DOI: 10.1161/01.cir.99.20.2694

Field-Weighted Citation Impact: 14.64