Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

2009299 citationsJournal Articlebronze Open Access

Authors

Sha Mi · Biogen (United States)

Robert H. Miller · Case Western Reserve University

Wei Tang · Biogen (United States)

Xinhua Lee · Biogen (United States)

Bing Hu · University of Hong Kong

Wutain Wu · University of Hong Kong

Yiping Zhang ·

Abstract

Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination.

Topics & Keywords

Neurogenesis and neuroplasticity mechanisms Multiple Sclerosis Research Studies Nerve injury and regeneration

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 65, Issue 3, pp. 304-315

DOI: 10.1002/ana.21581

Field-Weighted Citation Impact: 10.30