Association Between Metabolic Syndrome and Liver Histology Among Children With Nonalcoholic Fatty Liver Disease

2010188 citationsJournal Articlegreen Open Access

Authors

Heather Patton · University of California, San Diego

Katherine P. Yates · Johns Hopkins University

Aynur Ünalp–Arida · Johns Hopkins University

Cynthia Behling

Terry T.‐K. Huang · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Philip Rosenthal · University of California, San Francisco

Arun J. Sanyal · Virginia Commonwealth University

Abstract

MetS is common among children with NAFLD and is associated with severity of steatosis, hepatocellular ballooning, NAS, NAFLD pattern, and the presence of advanced fibrosis. Individual MetS features, particularly central obesity and insulin resistance, were also associated with severity of NAFLD. MetS features should be considered in children with NAFLD as individually and collectively they help identify children with more advanced disease.

Topics & Keywords

Liver Disease Diagnosis and Treatment Pancreatitis Pathology and Treatment Diet, Metabolism, and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

Volume 105, Issue 9, pp. 2093-2102

DOI: 10.1038/ajg.2010.152

Field-Weighted Citation Impact: 8.72