Uptake of <sup>99m</sup>Tc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: Associations with mania

199798 citationsJournal Article

Authors

Guy M. Goodwin · Warneford Hospital

Jonathan Cavanagh · University of Edinburgh

Michael F. Glabus · Medical Research Council

Robert Kehoe · Airedale General Hospital

Ronan E. O’Carroll · University of Stirling

Klaus P. Ebmeier · Royal Edinburgh Hospital

Abstract

The important effect of lithium withdrawal on brain perfusion implies that after withdrawal of lithium, the brain develops an abnormal state of activity in limbic cortex. The structures involved did not co-localise with those apparently modulated by manic symptoms.

Topics & Keywords

Bipolar Disorder and Treatment Electrolyte and hormonal disorders Schizophrenia research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The British Journal of Psychiatry

Volume 170, Issue 5, pp. 426-430

DOI: 10.1192/bjp.170.5.426

Field-Weighted Citation Impact: 3.03