Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells

2013105 citationsJournal Articlebronze Open Access

Authors

Xuli Zhao · University of Pennsylvania

Zeyong Yang · Zhongshan Hospital

Liang Ge · University of Pennsylvania

Zhen Wu · Huazhong University of Science and Technology

Yi Peng · University of Pennsylvania

Donald J. Joseph · University of Pennsylvania

Saadet Inan ·

Abstract

The commonly used general anesthetic isoflurane exerts dual effects on neuronal stem cell survival, proliferation, and differentiation, which may be attributed to differential regulation of calcium release through activation of endoplasmic reticulum localized inositol-1,4,5-trisphosphate and/or ryanodine receptors.

Topics & Keywords

Anesthesia and Neurotoxicity Research Intensive Care Unit Cognitive Disorders Cardiac Ischemia and Reperfusion

Publication Details

Published in: Anesthesiology

Volume 118, Issue 3, pp. 537-549

DOI: 10.1097/aln.0b013e3182833fae

Field-Weighted Citation Impact: 8.37

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Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells

Authors

Abstract

Topics & Keywords

Publication Details