Matrix Metalloproteinase-2 Inhibitors from <i>Clinopodium chinense</i> var. <i>parviflorum</i>

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Authors

Toshihiro Murata · Shizuoka Saiseikai General Hospital

Kenroh Sasaki · Komatsu (Japan)

Kumiko Sato · University of Shizuoka

Fumihiko Yoshizaki · Shizuoka Saiseikai General Hospital

Haruna Yamada · Shizuoka Saiseikai General Hospital

Hiromichi Mutoh · Komatsu (Japan)

Kaoru Umehara

Abstract

From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).

Topics & Keywords

Natural product bioactivities and synthesis Marine Sponges and Natural Products Phytochemical compounds biological activities

Publication Details

Published in: Journal of Natural Products

Volume 72, Issue 8, pp. 1379-1384

DOI: 10.1021/np800781t

Field-Weighted Citation Impact: 1.57

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Matrix Metalloproteinase-2 Inhibitors from <i>Clinopodium chinense</i> var. <i>parviflorum</i>

Authors

Abstract

Topics & Keywords

Publication Details