Allelic Combinations of Immune-Response Genes as Possible Composite Markers of IFN-β Efficacy in Multiple Sclerosis Patients

201217 citationsJournal Article

Authors

О. Г. Кулакова · Pirogov Russian National Research Medical University

Ekaterina Tsareva · Institute of Experimental Cardiology

Alexey Boyко · Pirogov Russian National Research Medical University

С Г Щур

Е. И. Гусев · Pirogov Russian National Research Medical University

Dmitrijs Lvovs · Kurchatov Institute

Alexander V. Favorov · Genetika

Abstract

The data obtained provides evidence of the cumulative effect of immune-response genes on IFN-β treatment efficacy. This joint contribution may reflect the additive effect of independent allelic variants and epistatic interactions between some of them.

Topics & Keywords

Multiple Sclerosis Research Studies Cytokine Signaling Pathways and Interactions Mycobacterium research and diagnosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pharmacogenomics

Volume 13, Issue 15, pp. 1689-1700

DOI: 10.2217/pgs.12.161

Field-Weighted Citation Impact: 0.79