The effect of age on the pharmacokinetics and pharmacodynamics of midazolam

1999144 citationsJournal Article

Authors

Susanne Albrecht · Roche (Switzerland)

Harald Ihmsen · Friedrich-Alexander-Universität Erlangen-Nürnberg

W. Hering · Friedrich-Alexander-Universität Erlangen-Nürnberg

Gerd Geißlinger · Friedrich-Alexander-Universität Erlangen-Nürnberg

Jasper Dingemanse · Friedrich-Alexander-Universität Erlangen-Nürnberg

H. Schwilden · Friedrich-Alexander-Universität Erlangen-Nürnberg

J. Schüttler

Abstract

These results suggest that the lower doses needed to reach sedation in the elderly subjects were attributable to a 50% decrease in EC50, not to changes in pharmacokinetics.

Topics & Keywords

Anesthesia and Sedative Agents Epilepsy research and treatment Intensive Care Unit Cognitive Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 65, Issue 6, pp. 630-639

DOI: 10.1016/s0009-9236(99)90084-x

Field-Weighted Citation Impact: 3.87