Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes

2012330 citationsJournal Article

Authors

Mina Komuta · KU Leuven

Olivier Govaere · KU Leuven

Vincent Vandecaveye · KU Leuven

Jun Akiba · Kurume University

Werner Van Steenbergen · KU Leuven

Chris Verslype · KU Leuven

Wim Laleman · KU Leuven

Abstract

Muc-ICCs had a clinicopathological, immunohistochemical, and molecular profile similar to that of hilar CCs (from mucin-producing cholangiocytes), whereas mixed-ICCs had a profile similar to that of CLCs (thought to be of HPC origin), possibly reflecting their respective cells of origin.

Topics & Keywords

Cholangiocarcinoma and Gallbladder Cancer Studies Cancer-related gene regulation MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 55, Issue 6, pp. 1876-1888

DOI: 10.1002/hep.25595

Field-Weighted Citation Impact: 21.44