Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

2008139 citationsJournal Articlegold Open Access

Authors

Ugo Ala · University of Turin

Rosario M. Piro · University of Turin

Elena Grassi · University of Turin

Christian Damasco · University of Turin

Lorenzo Silengo · University of Turin

Martin Oti · Radboud University Nijmegen

Paolo Provero ·

Abstract

Our results demonstrate that conserved coexpression, even at the human-mouse phylogenetic distance, represents a very strong criterion to predict disease-relevant relationships among human genes.

Topics & Keywords

Bioinformatics and Genomic Networks Gene expression and cancer classification Genomics and Chromatin Dynamics

Publication Details

Published in: PLoS Computational Biology

Volume 4, Issue 3, pp. e1000043-e1000043

DOI: 10.1371/journal.pcbi.1000043

Field-Weighted Citation Impact: 6.75

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Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

Authors

Abstract

Topics & Keywords

Publication Details