Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer

2000142 citationsJournal Article

Authors

Pierre L. Triozzi · The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Reema Khurram · The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Wayne Aldrich · The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Michael J. Walker · The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Julian A. Kim · The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Abstract

This pilot study demonstrates that DCs derived in vitro can exist viably after intratumoral injection and can mediate biologic activity in situ. Tumor-derived heat shock proteins may be involved in the antitumor activity observed.

Topics & Keywords

Immunotherapy and Immune Responses Heat shock proteins research T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 89, Issue 12, pp. 2646-2654

DOI: 10.1002/1097-0142(20001215)89:12<2646::aid-cncr18>3.0.co;2-a

Field-Weighted Citation Impact: 3.17