The Pharmacokinetics and Pharmacodynamics of Liposome Bupivacaine Administered Via a Single Epidural Injection to Healthy Volunteers

Epidurally administered liposome bupivacaine 266 mg resulted in a longer duration of sensory blockade than liposome bupivacaine 89 or 155 mg or bupivacaine HCl 50 mg. Duration of motor blockade was shorter with liposome bupivacaine 266 mg versus bupivacaine HCl.