Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

2013240 citationsJournal Articlebronze Open Access

Authors

Su‐Mi Choi · Sidney Kimmel Comprehensive Cancer Center

Yonghak Kim · Sidney Kimmel Comprehensive Cancer Center

Joong Sup Shim · Johns Hopkins Medicine

Joon Tae Park · Johns Hopkins University

Rui-Hong Wang · National Institute of Diabetes and Digestive and Kidney Diseases

Steven D. Leach · Johns Hopkins University

Jun O. Liu

Abstract

Our results demonstrated the feasibility of effective large-scale drug screening using an iPSC-based disease model and highly robust gene targeting in human iPSCs, both of which are critical for translating the iPSC technology into novel therapies for untreatable diseases.

Topics & Keywords

Hippo pathway signaling and YAP/TAZ Pluripotent Stem Cells Research CRISPR and Genetic Engineering

Publication Details

Published in: Hepatology

Volume 57, Issue 6, pp. 2458-2468

DOI: 10.1002/hep.26237

Field-Weighted Citation Impact: 17.77

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Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

Authors

Abstract

Topics & Keywords

Publication Details