Population Pharmacokinetics of Propofol

2000435 citationsJournal Articlebronze Open Access

Authors

J. Schüttler · Friedrich-Alexander-Universität Erlangen-Nürnberg

Abstract

Pharmacokinetics of propofol can be well described by a three-compartment model. Inclusion of age and weight as covariates significantly improved the model. Adjusting pharmacokinetics to the individual patient should improve the precision of target-controlled infusion and may help to broaden the field of application for target-controlled infusion systems.

Topics & Keywords

Anesthesia and Sedative Agents Antibiotics Pharmacokinetics and Efficacy Epilepsy research and treatment

Publication Details

Published in: Anesthesiology

Volume 92, Issue 3, pp. 727-738

DOI: 10.1097/00000542-200003000-00017

Field-Weighted Citation Impact: 14.34

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Population Pharmacokinetics of Propofol

Authors

Abstract

Topics & Keywords

Publication Details