Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

19901,149 citationsJournal Article

Authors

Kevin W. Moore · Palo Alto Institute

Paulo Vieira · Palo Alto Institute

David Fiorentino · Palo Alto Institute

Mary Trounstine · Palo Alto Research Center

Tariq A. Khan · Palo Alto Research Center

Timothy R. Mosmann · Palo Alto Institute

Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by T H 1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

Topics & Keywords

Herpesvirus Infections and Treatments Viral-associated cancers and disorders Cytomegalovirus and herpesvirus research

Publication Details

Published in: Science

Volume 248, Issue 4960, pp. 1230-1234

DOI: 10.1126/science.2161559

Field-Weighted Citation Impact: 69.21

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Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

Authors

Abstract

Topics & Keywords

Publication Details