Clinical Features of Schizophrenia and Linkage to Chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families

These results raise the possibility that the putative susceptibility gene for schizophrenia localized in the 8p22-8p21 region may predispose individuals to the core dementia-praecox syndrome described by Kraepelin more than 100 years ago.