Gender Differences in Pharmacokinetics of Alcohol

2001557 citationsJournal Article

Authors

Enrique Baraona · Veterans Health Administration

Chaim S. Abittan · Icahn School of Medicine at Mount Sinai

Kazufumi Dohmen · Icahn School of Medicine at Mount Sinai

Michelle Moretti · Icahn School of Medicine at Mount Sinai

Gabriele Pozzato · Icahn School of Medicine at Mount Sinai

Zev W. Chayes · Icahn School of Medicine at Mount Sinai

Clara Schaefer

Abstract

The gender difference in alcohol levels is due mainly to a smaller gastric metabolism in females (because of a significantly lesser activity of chi-ADH), rather than to differences in gastric emptying or in hepatic oxidation of ethanol. The concentration-dependency of these effects may explain earlier discrepancies. The combined pharmacokinetic differences may increase the vulnerability of women to the effects of ethanol.

Topics & Keywords

Alcohol Consumption and Health Effects Diet and metabolism studies Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alcoholism Clinical and Experimental Research

Volume 25, Issue 4, pp. 502-507

DOI: 10.1111/j.1530-0277.2001.tb02242.x

Field-Weighted Citation Impact: 6.84