Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

2008752 citationsJournal Articlebronze Open Access

Authors

Deborah J. Smyth · Juvenile Diabetes Research Foundation

Vincent Plagnol · Wellcome Trust

Neil Walker · Wellcome Trust

Jason D. Cooper · Addenbrooke's Hospital

Kate Downes · Wellcome Trust

Jennie H. M. Yang · Addenbrooke's Hospital

Joanna M. M. Howson ·

Abstract

A genetic susceptibility to both type 1 diabetes and celiac disease shares common alleles. These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases.

Topics & Keywords

Celiac Disease Research and Management Diabetes and associated disorders Digestive system and related health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 359, Issue 26, pp. 2767-2777

DOI: 10.1056/nejmoa0807917

Field-Weighted Citation Impact: 41.69