Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy

201048 citationsJournal Article

Authors

Bijan S. Kheirabadi · United States Army Institute of Surgical Research

James E. Mace · United States Army Institute of Surgical Research

Irasema B. Terrazas · United States Army Institute of Surgical Research

Chriselda G. Fedyk · United States Army Institute of Surgical Research

Krystal K. Valdez · United States Army Institute of Surgical Research

Martin J. MacPhee · United States Army Institute of Surgical Research

Abstract

The tissue sealant property of WS is apparently mediated by clot formation in the wound; therefore, it was ineffective under coagulopathic conditions. CG was partially effective in maintaining blood pressure up to 1 hour after application. FAST dressing showed the highest efficacy because of the exogenous delivery of concentrated fibrinogen and thrombin to the wound, which bypasses coagulopathy and secures hemostasis.

Topics & Keywords

Trauma, Hemostasis, Coagulopathy, Resuscitation Hemostasis and retained surgical items Muscle and Compartmental Disorders

Publication Details

Published in: The Journal of Trauma: Injury, Infection, and Critical Care

Volume 69, Issue 5, pp. 1062-1073

DOI: 10.1097/ta.0b013e3181fa0f21

Field-Weighted Citation Impact: 3.13

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Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy

Authors

Abstract

Topics & Keywords

Publication Details