Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

200991 citationsJournal Article

Authors

Phyllis Chew · Baker Heart and Diabetes Institute

Derek Y.C. Yuen · Baker Heart and Diabetes Institute

Philip Koh · Baker Heart and Diabetes Institute

Nada Stefanovic · Baker Heart and Diabetes Institute

Mark A. Febbraio · Baker Heart and Diabetes Institute

Ismail Kola · Baker Heart and Diabetes Institute

Mark E. Cooper

Abstract

Ebselen reduces atherosclerotic lesions in most regions of diabetic apoE(-/-) aorta, except within the aortic sinus, suggesting its effectiveness as a potential antiatherogenic therapy in diabetic-macrovascular disease. Ebselen may elicit its effect via modulation of transcription factors such as NF-kappaB and AP-1.

Topics & Keywords

Redox biology and oxidative stress Organoselenium and organotellurium chemistry Advanced Glycation End Products research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 29, Issue 6, pp. 823-830

DOI: 10.1161/atvbaha.109.186619

Field-Weighted Citation Impact: 3.23