Microsatellite instability and MLH1 hypermethylation – incidence and significance in colorectal polyps in young patients

200714 citationsJournal Article

Authors

Dean C. Koh · Grand Rapids Public Museum

Martin Luchtefeld

D. G. Kim

Houssam Attal · Spectrum Health

Thomas Monroe · Spectrum Health

Kimberly Ingersoll · Spectrum Health

Abstract

MLH1 HM was found in approximately 16% of polyps found in young patients and represents one of the epigenetic changes that may result in the subsequent progression to carcinoma along an accelerated sequence. The yield of MSI testing in these patients is low and is not recommended.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Screening and Detection Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Colorectal Disease

Volume 9, Issue 6, pp. 521-526

DOI: 10.1111/j.1463-1318.2007.01175.x

Field-Weighted Citation Impact: 0.57