Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver

2002121 citationsJournal Article

Authors

Yasushi Magami · Tokyo Medical University

Takeshi Azuma · Shiga University of Medical Science

Hideto Inokuchi · Shiga University of Medical Science

Shinichiro Kokuno · Shiga University of Medical Science

Fuminori Moriyasu · Shiga University of Medical Science

Keiichi Kawai · Shiga University of Medical Science

Takanori Hattori

Abstract

The present study indicated that most cells in the liver arise postnatally. The changes in labeling of cells show that there is no special zone for proliferation of hepatocytes and they renew in all regions of the hepatic lobule, suggesting (i) that hepatocytes are supplied by postnatal replication and (ii) streaming of hepatocytes from periportal to pericentral regions does not occur in the adult mouse liver. The bile duct cells renewed more rapidly than hepatocytes.

Topics & Keywords

Liver physiology and pathology Organ Transplantation Techniques and Outcomes Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Liver International

Volume 22, Issue 5, pp. 419-425

DOI: 10.1034/j.1600-0676.2002.01702.x

Field-Weighted Citation Impact: 0.29