Cigarette Smoking Impairs Human Pulmonary Immunity to <i>Mycobacterium tuberculosis</i>

2014134 citationsJournal Article

Authors

Seónadh M. O’Leary · Trinity College Dublin

Michelle M. Coleman · Trinity College Dublin

Wui Mei Chew · Trinity College Dublin

Colette Morrow

Anne Marie McLaughlin · St. James's Hospital

Laura E. Gleeson · Trinity College Dublin

Mary P. O’Sullivan · Trinity College Dublin

Abstract

In smokers, the pulmonary compartment has a number of macrophage-specific immune impairments that provide some mechanistic explanations whereby cigarette smoking renders a patient susceptible to tuberculosis infection and disease.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Helicobacter pylori-related gastroenterology studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 190, Issue 12, pp. 1430-1436

DOI: 10.1164/rccm.201407-1385oc

Field-Weighted Citation Impact: 5.57